{"id":1259,"date":"2018-01-21T01:44:42","date_gmt":"2018-01-21T00:44:42","guid":{"rendered":"https:\/\/cosys.chimie.unistra.fr\/?page_id=1259"},"modified":"2018-04-28T11:02:58","modified_gmt":"2018-04-28T10:02:58","slug":"palladium-cross-coupling","status":"publish","type":"page","link":"https:\/\/cosys.chimie.unistra.fr\/?page_id=1259","title":{"rendered":"Palladium Cross-Coupling"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1666 aligncenter\" src=\"https:\/\/cosys.chimie.unistra.fr\/wp-content\/uploads\/2018\/04\/Palladium.png\" alt=\"\" width=\"150\" height=\"159\" srcset=\"https:\/\/cosys.chimie.unistra.fr\/wp-content\/uploads\/2018\/04\/Palladium.png 595w, https:\/\/cosys.chimie.unistra.fr\/wp-content\/uploads\/2018\/04\/Palladium-283x300.png 283w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/p>\n<p style=\"text-align: justify;\"><strong>Palladium Catalyzed Cross-Coupling Reactions<\/strong> are nowadays essential to organic chemistry, allowing to conveniently build up complex molecules through C-C bond formation. These reactions usually involved two partners: a vinyl or aryl halide or triflate and different organometallic reagents, such as boronic acids or esters (Suzuki-Miyaura reaction), organotins (Stille reaction) and others, or alkenes (Mirozoki-Heck reaction) or alkynes (Sonogashira reaction). However, limitations still exist regarding the conditions but also the starting material nature. Iodides and bromides are more reactive but for industrial and cost reasons, chlorides can now be used, although they required harsher conditions and\/or specific catalysts. Triflates usually are as reactive as iodides, but their introduction through triflic anhydride requires specific conditions due to the sensitivity of this reagent. However, other inexpensive sulfonates such as <strong>nosylate<\/strong> and <strong>tosylate<\/strong> derivatives can offer a convenient alternative to traditional halide or triflate partners.<\/p>\n<h6><span style=\"color: #004079;\"><strong>Aryl or Vinyl Nosylates as Versatile Partners<\/strong><\/span><\/h6>\n<p>For the first time, we have demonstrated that <em>para-<\/em>nitrophenylsulfonate (nosyl; Ns) group act as a chip and excellent partner in various Pd-catalyzed cross-coupling reactions.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-1763 size-full\" title=\"Aryl or Vinyl Nosylates as Versatile Partners\" src=\"https:\/\/cosys.chimie.unistra.fr\/wp-content\/uploads\/2018\/04\/Diapositive7.png\" alt=\"\" width=\"723\" height=\"223\" srcset=\"https:\/\/cosys.chimie.unistra.fr\/wp-content\/uploads\/2018\/04\/Diapositive7.png 723w, https:\/\/cosys.chimie.unistra.fr\/wp-content\/uploads\/2018\/04\/Diapositive7-300x93.png 300w\" sizes=\"auto, (max-width: 723px) 100vw, 723px\" \/><\/p>\n<p>&nbsp;<\/p>\n<h6><span style=\"color: #004079;\"><strong>Tosylates as Convenient Partners for Heteroaryl Derivatives Synthesis<\/strong><\/span><\/h6>\n<p>We are also working on the development of efficient conditions for unprecedented Suzuki-Miyaura cross-coupling reactions between heteroaryl tosylates and boronic acids to achieve the total synthesis of Rhazinal alkaloid.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-1764 size-full\" title=\"Tosylates as Convenient Partners for Heteroaryl Derivatives Synthesis\" src=\"https:\/\/cosys.chimie.unistra.fr\/wp-content\/uploads\/2018\/04\/Diapositive8.png\" alt=\"\" width=\"510\" height=\"153\" srcset=\"https:\/\/cosys.chimie.unistra.fr\/wp-content\/uploads\/2018\/04\/Diapositive8.png 510w, https:\/\/cosys.chimie.unistra.fr\/wp-content\/uploads\/2018\/04\/Diapositive8-300x90.png 300w\" sizes=\"auto, (max-width: 510px) 100vw, 510px\" \/><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Palladium Catalyzed Cross-Coupling Reactions are nowadays essential to organic chemistry, allowing to conveniently build up complex molecules through C-C bond formation. These reactions usually involved two partners: a vinyl or aryl halide or triflate and different organometallic reagents, such as boronic acids or esters (Suzuki-Miyaura reaction), organotins (Stille reaction) and others, or alkenes (Mirozoki-Heck reaction) [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1259","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/cosys.chimie.unistra.fr\/index.php?rest_route=\/wp\/v2\/pages\/1259","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cosys.chimie.unistra.fr\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/cosys.chimie.unistra.fr\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/cosys.chimie.unistra.fr\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/cosys.chimie.unistra.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1259"}],"version-history":[{"count":7,"href":"https:\/\/cosys.chimie.unistra.fr\/index.php?rest_route=\/wp\/v2\/pages\/1259\/revisions"}],"predecessor-version":[{"id":1777,"href":"https:\/\/cosys.chimie.unistra.fr\/index.php?rest_route=\/wp\/v2\/pages\/1259\/revisions\/1777"}],"wp:attachment":[{"href":"https:\/\/cosys.chimie.unistra.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1259"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}